CAN NSAIDs CONTINUE TO BE RECOMMENDED FOR INFLAMMATION?
Recent research on breast cancer has revealed a confused result that aspirin and other NSAIDs are elevating and exacerbating the inflammatory condition in breast cancer.
The study is interesting as it goes against the result of the previous study result in the research on the benefits of aspirin in colorectal cancer.
Regular long time use of aspirin and other NSAIDs is associated with an increased risk of dying in patients suffering from type-1 endometrial cancer. A new study led by the researchers in Ohio State University Comprehensive Cancer Center -Arthur C.James Cancer Hospital and Richard J.Solove Institute.(OSUCCC-James)
In this multinational observational study the team of cancer researchers sought to find out the association of regular use of NSAIDs use and the risk of dying of endometrial cancer among a cohort of more than 4000 patients.
The study revealed that about more than 60% of the population are associated with the risk of dying with the elevated conditions of endometrial cancers among women with type-1 endometrial cancers which is typically less aggressive than type-2.
The association was statistically significant among patients who reported the use of NSAIDs in the past and in present at the time of diagnosis. It was strongest among patients who used the NSAIDs for more than 10 years but stopped at the time of diagnosis.
The use of NSAIDs are not increasing the mortality rate among those who suffer the more aggressive type-2 endometrial cancers.
It has been found out that chronic inflammation plays an important role in developing cancer and the recent study has shown that inhibition of inflammation also plays a role, said by Theodore Brasky Ph.D.,co-lead author, and cancer epidemiologist in OHUCCC-James.
Dr.Ashley Felix Ph.D., a cancer epidemiologist and one of the research team in OHUCCC-James said that they are continuing the study of the biologic mechanism by which inflammation is related to cancer.
Disclaimer
The above research has given us an outline knowledge of the association of NSAIDs to the increasing number of deaths among women with type-1 endometrial cancer and not a thorough and confirmed result.
Women with endometrial cancer are far more likely to die of cardiovascular problems than cancer itself. Hence those who are taking NSAIDs for their cardiovascular problems (e.g.aspirin for heart attack) should continue it under medical supervision.
